Protein Details: Transient receptor potential channel mucolipin 2

Protein ID

ICDB_Pro_1267

Protein Name

Transient receptor potential channel mucolipin 2

Gene Name

Mcoln2

Organism

Mus musculus (Mouse)

Length

566 amino acids

AlphaFoldDB

AF-Q8K595-F1-model_v4.pdb

Function

Sequence

MPGDEETLDLPAWNRVPDLTWGPHHRSAMASLDSEVREECLREDLKFYFMSPCEKYRARRQIPWKLGLQILKIVMVTTQLVRFGLSNQLVVAFKEDNTVAFKHLFLKGFSGVDEDDYSCSIYTQENTYESIFFAIKQYRHLKNISLATLGYGESEDNRTGLKVCKQHYKTGAMFSSNETLNIDSDIETDCIHLDLQVLTTEPEDWAQTSFFRLDFYRLVQVDISFALKGIDLQAVHSREIPDCYLFQNTITFDNTAHSGKIKIYLNSEANIEECKNMNISGSTQRSTHYLLVFDVFVIMICLASLILCTRSIVLALRLRKRFLNFFLEKYKQRVCGADQWEFVNGWYVLVTISDLMTIIGSILKMEIKAKKLTNYDVCSILLGTSTLFVWVGVIRYLGYFQTYNVLILTMQASLPKVLRFCACAGMIYLGYTFCGWIVLGPYHEKFENLNIVAECLFSLVNGDDMFATFAQIQQKSILVWLFSRLYLYSFISLFIYMVLSLFIALITDSYHTIKKYQQHGFPETDLQKFLKESGSKDGYQKQPSALLSCLCCLRRRRSNDHLILID

PDB Structures

7DYS

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

Isoform 1 is widely expressed at very low levels. Isoform 2 is expressed at high levels in lymphoid tissues (thymus and spleen) and kidney; and at moderate levels in heart; lung; liver and stomach. Expressed in activated macrophages and microglia (at protein level). Expressed in activated macrophages and microglia (at protein level). Expressed in activated macrophages and microglia (at protein level).

DOI ID

10.1073/pnas.222425399; 10.1126/science.1112014; 10.1101/gr.2596504; 10.1016/j.ejcb.2006.08.004; 10.1007/s00424-009-0716-5; 10.1074/jbc.m112.368876; 10.4049/jimmunol.1500163

RefSeq

NP_001005846.1 [Q8K595-2]; NP_080932.2 [Q8K595-1];